Analysis of the specific hemorheological effects of low molecular weight dextran (LMWD)- and saline-infusions in healthy volunteers

Abstract

The flow properties of blood were measured with various methods (rheologic analysis battery) before and after the infusion of 500 ml of a) 10 % low molecular weight dextran solution and b) of a 0,9 % sodium chloride solution in healthy volunteers. LMWD decreases blood viscosity, but increases plasma viscosity. Red cell filtration is decreased. There is no specific disaggregating effect of LMWD. After infusion of saline there is a transient decrease in blood and plasma viscosity, and an increase in filtration rate. No specific reduction in red cell aggregation could be found.