Cardiometabolic and traditional cardiovascular risk factors and their potential impact on macrovascular and microvascular function: Preliminary data

Abstract

We studied the relationship between cardiovascular status (CV) and risk factor numbers, macrovascular (flow mediated dilatation: FMD) and microvascular function using near-infrared spectroscopy (NIRS) in adults with different CV status. Seventy adults with different CV status (27 controls, 18 metabolic syndrome (MetS) and 25 coronary heart disease (CHD) patients) underwent a 5-min forearm arterial occlusion in supine position. High-resolution ultrasound examination of the brachial artery was performed during 1 minute at rest and 45 to 120 seconds after cuff release. Oxy, de-oxy and total hemoglobin signals (O₂Hb, HHb and tHb) were measured continuously with NIRS on brachio-radialis muscle. FMD was reduced in CHD patients (P < 0.05) compared to controls. Max. amplitude of O₂Hb and Hmax of tHb were reduced (P < 0.05) in MetS patients vs. controls. Post-deflation area under the curve (A.U.C) of O₂Hb was lower in CHD (P < 0.01) patients vs. controls and MetS patients. Independent predictors of microvascular function (A.U.C of O₂Hb) were abdominal obesity and LDL-cholesterol whereas macrovascular function (FMD) was predicted by CV status. Only A.U.C of O₂Hb related to CV risk numbers whereas FMD was not. Although macro and microvascular function were impaired in MetS and CHD patients, microvascular function was more strongly related to CV risk factors.