Usefulness of whole blood viscosity estimated by de Simeone’s formula to predict left ventricular thrombus formation within one year following acute anterior myocardial infarction
Restricted accessResearch articleFirst published online February, 2020
Usefulness of whole blood viscosity estimated by de Simeone’s formula to predict left ventricular thrombus formation within one year following acute anterior myocardial infarction
Despite improvements in treatment of ST-segment myocardial infarction (STEMI), thrombus formation in the left ventricle is still a concerning complication that may lead to systemic thromboembolism and stroke.
OBJECTIVES:
To evaluate the predictive value of estimated whole blood viscosity (WBV) for left ventricular thrombus development in patients surviving an acute anterior myocardial infarction (AAMI).
MATERIALS \& METHODS:
Seven hundred eighty AAMI patients who were treated percutaneously were enrolled consecutively. Serial echocardiographic examinations were performed within 24h of admission, before hospital discharge, and at 1, 3, 6 and 12 months following hospital discharge. WBV was calculated according to de Simones formula.
RESULTS:
One hundred patients (12.8%) developed thrombus formation within one year following AAMI. Patients with left ventricular thrombus (LVT) had significantly higher WBV values. Supramedian values of WBV at both low (0.5 sec−1) and high (208 sec−1) shear rates were found to be an independent predictor of LVT development.
CONCLUSION:
As an easily accessible parameter, WBV might be a useful predictor of LVT formation within one year following acute anterior myocardial infarction.
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