Restricted accessResearch articleFirst published online 2020-2
Usefulness of whole blood viscosity estimated by de Simeone’s formula to predict left ventricular thrombus formation within one year following acute anterior myocardial infarction
Despite improvements in treatment of ST-segment myocardial infarction (STEMI), thrombus formation in the left ventricle is still a concerning complication that may lead to systemic thromboembolism and stroke.
OBJECTIVES:
To evaluate the predictive value of estimated whole blood viscosity (WBV) for left ventricular thrombus development in patients surviving an acute anterior myocardial infarction (AAMI).
MATERIALS \& METHODS:
Seven hundred eighty AAMI patients who were treated percutaneously were enrolled consecutively. Serial echocardiographic examinations were performed within 24h of admission, before hospital discharge, and at 1, 3, 6 and 12 months following hospital discharge. WBV was calculated according to de Simones formula.
RESULTS:
One hundred patients (12.8%) developed thrombus formation within one year following AAMI. Patients with left ventricular thrombus (LVT) had significantly higher WBV values. Supramedian values of WBV at both low (0.5 sec−1) and high (208 sec−1) shear rates were found to be an independent predictor of LVT development.
CONCLUSION:
As an easily accessible parameter, WBV might be a useful predictor of LVT formation within one year following acute anterior myocardial infarction.
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