Influence of oxygen tensions,intracellular enzymes and hematological factors on RBC filterability

Abstract

Using a new automatic device and a standardised protocole for looking the filterability of erythrocytes through 5 μ pores, we introduced the IF (Index of Filterability) parameter. We demonstrate that IF is dependent on the viscoelastic properties of RBC membranes when Hb is normal, and dependent on Hb and O₂ saturation of Hb when Hb is unstable (Thalassemia or drepanocytosis). The molecular interpretation and the interest of that for clinical screening or extensive studies are discussed.