Abstract
Determination of the intrinsic viscosity of cattle synovial fluid, and hyaluronic acid preparations, from the data obtained with a Cannon-Manning semi-micro viscometer operated in the conventional manner (Newtonian fluid behavior and shear stress of 8.1 dynes/cm2) yielded results less than 6 per cent lower than when the data were treated for non-Newtonian fluid behavior and extrapolated to zero shear conditions.
Hyaluronic acid from several sources, prepared by two different purification procedures, yielded values of Huggins’ constant between 0.14 and 0.17, when the calculations were made under zero shear conditions. The value of k 1 appeared to be independent of intrinsic viscosity.
The intrinsic viscosity of hyaluronic acid prepared from synovial fluid of patients with rheumatoid arthritis was about half that of hyaluronic acid prepared from normal synovial fluid.
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