Abstract
Inflammatory breast cancer (IBC) presents with unique clinical characteristics (erythema, warming, peau d'orange), rapid progression, and poor survival compared to non-IBC breast cancers. Modern combined modality treatment has significantly improved overall survival. However, IBC treatment remains a major challenge. Recently, rapid progress has been made in the molecular characterization of IBC. In this review, we discuss the current advances in understanding the genetic determinants of IBC with emphasis on their present and potential applications to diagnosis, prognosis, and treatment.