A practical three-step synthetic approach to gimeracil in a 68% overall yield is described, using 2,4-dimethoxypyridine as the starting material with 3,5-dichloro-2,4-dimethoxypyridine and 3,5-dichloro-2,4-dihydroxypyridine as intermediates. The advantages of this procedure include short reaction steps, simple operation and good yield.
FurusakaT., TanakaA., MatsudaH. and IkedaM., Acta Otolaryngol., 2011, 131, 1099.
5.
PetersG.J., NoordhuisP., Van KuilenburgA.B.P., SchornagelJ.H., GallH., TurnerS.L., SwartM.S., VoornD., Van GennipA.H., WandersJ., HolwerdaU., SmidK., GiacconeG., FumoleauP. and Van GroeningenC.J., Cancer Chemother Pharmacol., 2003, 52, 1.
6.
den HertogH.J., CombeW.P. and KolderC.R., Recl. Trav. Chim. Pays-Bas, 1954, 73, 704.
7.
KolderC.R. and den HertogH.J., Recl. Trav. Chim. Pays-Bas, 1953, 72, 285.
8.
NagasawaH., HigurashiK. and YamanakaE., 10 October 2017, European Patent: 1842847.
9.
YanoS., OhnoT. and OgawaK., Heterocycles, 1993, 36, 145.
10.
ChengG., LiuX., LiuN., YeZ., BaoB., ShiP., LuoY. and LuW., 23 October 2013, Chinese Patent: 103360307.
11.
den HertogH.J. and OverhoffJ., Recl. Trav. Chim. Pays-Bas, 1950, 69, 468.
12.
SellW.J., J. Chem. Soc., Trans., 1912, 101, 1945.
13.
KolderC.R. and den HertogH.J., Recl. Trav. Chim. Pays-Bas, 1953, 72, 853.
