Free accessResearch articleFirst published online 2017-1
Design and Synthesis of (3,5-Disubstituted Isoxazole)-Linked [1,5]-Benzodiazepine Conjugates: Evaluation of their Antimicrobial and Anti-Tyrosinase Activities
A series of novel 2-(3,5-disubstituted isoxazolyl)-1,5-benzodiazepines and 2,4-bis-(3,5-disubstituted isoxazolyl)-1,5-benzodiazepine derivatives have been designed and synthesised by employing an alkyne/nitrile oxide cycloaddition ‘click’ type chemistry protocol. The structures of the compounds were determined on the basis of 1H, 13C and 2D-NMR techniques and by HRMS analysis. These hybrid molecules exhibit moderate to significant antimicrobial and anti-tyrosinase activities.
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