Abstract
A novel method for oxazine ring formation is established using the reaction of 4-hydroxy-6-methyl-2H-pyran-2-one and aromatic aldehydes with methyl carbamate in the presence of p-toluene sulfonic acid (p-TSA) in aqueous media to afford 4-aryl-7-methyl-3,4-dihydropyrano[3,4-e][1,3]oxazine-2,5-dione in excellent yields. The present method does not involve any hazardous organic solvents and could therefore be considered a green process.
Keywords
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