Free accessResearch articleFirst published online 2016-2
A Practical Approach for the Synthesis of Novel Triazolo-fused Benzazepine Derivatives Using a Multi-component Reaction and an Intramolecular C–H Arylation
An efficient and straightforward method has been developed for the preparation of triazolo-fused benzazepines by a facile, one-pot Ugi multi-component reaction/click reaction. In this strategy, the Ugi-reaction products were coupled by a click reaction, thus integrating the triazole fragment into the benzazepine structure using an intramolecular C–H arylation. The corresponding products were obtained in good yields without unfavourable by-products.
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