Abstract
A series of novel urea derivatives containing the 1,2,3-thiadiazole moiety were synthesised using microwave-assisted condensation reactions of 4-methyl-1,2,3-thiadiazole-5-carbohydrazide with various substituted isocyanatobenzenes in acetonitrile. Their chemical structures were characterised by 1H NMR, MS and elemental analysis. This method provides several advantages such as high yields, facile work-up and is environmentally friendly.
References
1.
Zhang
X. Y.
,
Li
Y. S.
,
Weng
J. Q.
, and
Tan
C. X.
, Chin. J. Org. Chem. , 2011 , 31 , 1295 .
2.
Guo
D. S.
, Chin. J. Org. Chem. , 2004 , 24 , 1118 .
3.
Zhou
H.Y.
,
Gong
R. J.
,
Miao
W. R.
, and
Qu
J. P.
, Fine Chem. , 2013 , 30 , 475 .
4.
Yang
M.Y.
,
Zhao
W.
,
Sun
Z. H.
,
Tan
C. X.
,
Weng
J. Q.
, and
Liu
X. H.
, Lett. Drug Des. Discov. , 2015 , 12 , 314 .
5.
Liu
X.H.
,
Sun
Z. H.
,
Yang
M. Y.
,
Tan
C. X.
,
Weng
J. Q.
,
Zhang
Y. G.
, and
Ma
Y.
, Chem. Biol. Drug Des. , 2014 , 84 , 342 .
6.
Liu
X.H
,
Xu
X. Y.
,
Tan
C. X.
,
Weng
J. Q.
,
Xin
J. H.
, and
Chen
J.
, Pest Manage. Sci. , 2015 , 71 , 292 .
7.
Yan
S.L.
,
Yang
M. Y.
,
Sun
Z. H.
,
Min
L. J.
,
Tan
C. X.
,
Weng
J. Q.
,
Wu
H. K.
, and
Liu
X. H.
, Lett. Drug Des. Discov. , 2014 , 11 , 940 .
8.
Zhang
L.J.
,
Yang
M. Y.
,
Sun
Z. H.
,
Tan
C. X.
,
Weng
J. Q.
,
Wu
H. K.
, and
Liu
X. H.
, Lett. Drug Des. Discov. , 2014 , 11 , 1107 .
9.
Liu
X.H.
,
Pan
L.
,
Ma
Y.
,
Weng
J. Q.
,
Tan
C. X.
,
Li
Y. H.
,
Shi
Y. X.
,
Li
B. J.
,
Li
Z. M.
, and
Zhang
Y. G.
, Chem. Biol. Drug Des. , 2011 , 78 , 689 .
10.
Yang
M.Y.
,
Sun
Z. H.
,
Liu
X. H.
,
Weng
J. Q.
, and
Tan
C. X.
, CN103724293, 2014 .
11.
Yang
M.Y.
,
Sun
Z. H.
,
Liu
X. H.
,
Weng
J. Q.
, and
Tan
C. X.
, CN103613564, 2014 .
12.
Zhang
L.J.
,
Yang
M. Y.
,
Hu
B. Z.
,
Sun
Z. H.
,
Liu
X. H.
,
Weng
J. Q.
, and
Tan
C. X.
, Turk. J. Chem. , 2015 , doi: 10.3906/kim-1408-78 available online at http://journals.tubitak.gov.tr/chem (epub prior to print).
13.
Liu
X. H.
,
Pan
L.
,
Weng
J. Q.
,
Tan
C. X.
,
Li
Y. H.
,
Wang
B. L.
, and
Li
Z. M.
, Mol. Divers. , 2012 , 16 , 251 .