Abstract
An effective, novel and rapid one-pot three-component route to quinazolin-4(3H)-ones from commercially available starting materials is described. Isatoic anhydride reacts with acyl chlorides and different amines using a combination of trifluoromethanesulfonic anhydride (Tf2O) and 2-chloropyridine (2-ClPy) to produce the corresponding quinazolinone derivatives in good to excellent yields.
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