Abstract
A synthesis of haloisoquinolines through electrophilic cyclisation involving an electrophilic-exchange process has been developed. A variety of 2-alkynyl benzyl azides are cyclised in the presence of KX (X = I, Br, Cl) and electrophilic fluoride reagents, to afford the corresponding haloisoquinolines in moderate to good yields. Reagents for electrophilic halogenation have been generated from their inorganic salts (M+X-) by oxidation with a Selectfluor reagent and reacted in situ with the substrates.
Keywords
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