Synthesis of Novel Heterocycle Systems: 6,8-Dimethyl-2-(Methylsulfanyl)-4-Amino-Substituted Pyrimido[4′,5′:3,4]Pyrazolo[1,5- a ]Pyrimidine and 9,11-Dimethyl-5-(Methylsulfanyl)Pyrimido[2′,1′:5,1]Pyrazolo[4,3- e ][1,2,4] Triazolo[4,3- c ]Pyrimidine
Free accessResearch articleFirst published online November, 2014
Synthesis of Novel Heterocycle Systems: 6,8-Dimethyl-2-(Methylsulfanyl)-4-Amino-Substituted Pyrimido[4′,5′:3,4]Pyrazolo[1,5- a ]Pyrimidine and 9,11-Dimethyl-5-(Methylsulfanyl)Pyrimido[2′,1′:5,1]Pyrazolo[4,3- e ][1,2,4] Triazolo[4,3- c ]Pyrimidine
The novel heterocyclic pyrimidopyrazolopyrimidine system was synthesised through cyclisation of 4-hydrazinyl-2,6-bis(methylthio)pyrimidine-5-carbonitrile with acetylacetone in high yield. Also, two other tetracyclic systems were synthesised through cyclisation of 4-hydrazinyl-6,8-dimethyl-2-(methylsulfanyl)pyrimido[4′,5′:3,4]pyrazolo[1,5-a]pyrimidine with triethyl orthoformate and sodium nitrite to obtain the pyrimidopyrazolotriazolo pyrimidine and pyrimidopyrazolotetrazolopyrimidine respectively.
