Free accessResearch articleFirst published online 2014-6
Stereoselective Synthesis of 1′,5′,7′,8′-Tetrahydro-2′ H,4′ H -Dispiro[[1,3] Dioxane-5,3′-Quinoline-6′,5″-[1″,3″]Dioxane]-4,4″,6,6″-Tetrone Derivatives in the Presence of Benzoic Acid as an Efficient Catalyst Via One-Pot Multicomponent Reaction
A simple and efficient pseudo eight-component synthesis of 1′,5′,7′,8′-tetrahydro-2′H,4′H-dispiro[[1,3]dioxane-5,3′-quinoline-6′,5″-[1″,3″]dioxane]-4,4″,6,6″-tetrone derivatives is described. This reaction between, aromatic aldehydes, aromatic amines and Meldrum's acid in the presence of benzoic acid as an efficient catalyst at ambient temperature affords the product in good yields.
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