Efficient Synthesis of 3,4-Dihydro-1 H -Quinoxalin-2-ones and 1 H -Quinolin-2-Ones and Evaluation of Their Anti-Bacterial Activity

Abstract

Economical and environmentally friendly syntheses of three 3,4-dihydro-1H-quinoxalin-2-ones and six 1H-quinolin-2-ones have been developed by a 1: 1 reaction of o-, m-, or p-phenylenediamine with dialkyl acetylenedicarboxylates under solvent-free conditions. Some of the products were antibacterial towards both Gram positive and Gram negative microorganisms.