A new tremulane sesquiterpene, ceriponol P, has been isolated from the cultures of Ceriporia lacerate, together with three known metabolites 3-indolecarbaldehyde, 3-methyl-2-indolinone, and daucosterol. Its structure was established by detailed analysis of its spectroscopic data, especially 1D, 2D NMR and HR-ESI-MS data. Ceriponol P represents the first example of monocyclic tremulane sesquiterpene. In biological assays, ceriponol P did not exhibit any significant cytotoxicity against HeLa, HepG2, and SGC 7901 cell lines at a concentration of 20 μM. All the known compounds were reported for the first time from the genus Ceriporia.
NakajimaE., NakanoH., YamadaK., ShigemoriH., and HasegawaK., Phytochemistry, 2002, 61, 863.
10.
Spectral Data Base for Organic Compounds (SDBS), National Institute of Advanced Industrial Science and Technology (AIST), Japan. BerlinA., and CanavesiA., Tetrahedron, 1996, 52, 7947.
11.
IsobeT., OhsakiA., and NagataK.Yakugaku Zasshi, 2002, 4, 291.
12.
LiuD.Z., WangF., and LiuJ.K., J. Nat. Prod., 2007, 70, 1503.
13.
AyerW.A., and CruzE.R., J. Org. Chem., 1993, 58, 7529.
14.
ZhouZ.Y., TangJ.G., WangF., DongZ.J., and LiuJ.K., J. Nat. Prod., 2008, 71, 1423.
15.
YangX.Y., FengT., YinX., LiZ.H.Z.H., ZhangL., and LiuJ.K., Chin. J. Chem., 2012, 30, 1231.
16.
WuX.L., LinS., ZhuC.G., YueZ.G., YuY., ZhaoF., LiuB., DaiJ.G., and ShiJ.G., J. Nat. Prod., 2010, 73, 1294.
