Abstract
New 3H-pyrazolo[4,3-a]acridine derivatives have been prepared by the reaction of 1-alkyl-5-nitro-1H-indazole with phenylacetonitrile and 2-(4-bromophenyl)acetonitrile in basic conditions via the nucleophilic substitution of hydrogen and concomitant cyclisation. The new compounds exhibited potent antibacterial activities and their antibacterial activities against Gram positive (Staphylococcus aureus, methicillin resistant S. aureus and Bacillus subtilis) and Gram negative bacterial (Pseudomonas aeruginosa and Escherichia coli) species were determined. The fluorescence properties of these derivatives were also studied.
Keywords
References
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