Free accessResearch articleFirst published online 2014-1
SiO 2 –OSO 3 H Nanoparticles: An Efficient,Versatile and New Reagent for the One-Pot Synthesis of 2-Amino-8-Oxo-4,8-Dihydropyrano[3,2- b ]Pyran-3-Carbonitrile Derivatives in Water,a Green Protocol
In a one-pot three-component reaction, an aromatic or aliphatic aldehyde, malononitrile and 5-hydroxy-2-hydroxymethyl-4H-pyran-4-one were condensed for the synthesis of 2-amino-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile derivatives in the presence of nano-silica sulfuric acid (SiO2–OSO3H nanoparticles) in improved yields. The catalyst is recoverable by simple filtration and can be used in the subsequent reactions.
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