Abstract
A new method for the construction of isoindolones is presented in this paper. Four 7-methyl-2-(8-quinolinyl)-2,3-dihydro-1H-isoindol-1-ones were synthesised from 2,6-dimethyl -N-(8-quinolinyl)benzamides via intramolecular direct amination of benzylic C–H bonds. This approach provides a convenient method affording structurally new isoindolones for medicinal chemistry research.
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