Abstract
A series of new N-heterocyclic or phenoxy substituted roflumilast analogues have been designed and synthesised. N-heterocyclic or phenoxy substituted benzaldehydes were first prepared from 3-hydroxy-4-methoxybenzaldehbyde and 1-bromo-3-chloropropane by an alkylation reaction. The roflumilast analogues were then obtained by oxidation, acylation, amidation and alkylation reactions. These compounds were characterised by 1H NMR, IR, ESI-MS and elemental analyses.
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