Synthesis of Dialkyl {(aryl)[2,2-Dimethyl-4-oxo-6-(Piperidin-1-yl)-4 H -[1,3]Dioxin-5-yl]Methyl}Phosphonate by Reaction of Meldrum's Acid,Aryl Aldehydes and Trialkyl Phosphites in the Presence of Piperidine
Free accessResearch articleFirst published online July, 2013
Synthesis of Dialkyl {(aryl)[2,2-Dimethyl-4-oxo-6-(Piperidin-1-yl)-4 H -[1,3]Dioxin-5-yl]Methyl}Phosphonate by Reaction of Meldrum's Acid,Aryl Aldehydes and Trialkyl Phosphites in the Presence of Piperidine
A four-component reaction between Meldrum's acid, aryl aldehydes with trialkyl phosphites in the presence of piper-idine has been developed. The reaction affords dialkyl {(aryl)[2,2-dimethyl-4-oxo-6-(piperidin-1-yl)-4H-[1,3]dioxin-5-yl]methyl}phosphonate in moderate to good yields in a one-pot process.
