Abstract
Novel substituted chromenes, chromenopyrimidines and chromenotriazolopyrimidines were synthesised to explore their anticancer activity. Several compounds were evaluated for their antitumour activity, most of them revealed promising cytotoxic activity against breast cancer cell line MCF-7 in comparison to colchicine as positive control.
Keywords
References
1.
Pellegrini
F.
, and
Budman
D.R.
, Cancer. Invest. , 2005 , 23 , 264 .
2.
Zef irova
O.N.
,
Diikov
A.G.
,
Zyk
N.V.
, and
Zef irov
N.S.
, Russ. Chem. Bull. , 2007 , 56 , 680 .
3.
Kemnitzer
W.
,
Drewe
J.
,
Jiang
S.
,
Zhang
H.
,
Wang
Y.
,
Zhao
J.
, J. Med. Chem. 2004 , 47 , 6299 .
4.
Afantitis
A.
,
Melagraki
G.
,
Sarimveis
H.
,
Koutentis
P.A.
,
Markopoulosd
J.
, and
Igglessi-Markopouloua
O.
, Bioorg. Med. Chem. , 2006 , 14 , 6686 .
5.
Sciabola
S.
,
Carosati
E.
,
Cucurull-Sanchez
L.
,
Baronic
M.
, and
Mannholdd
R.
, Bioorg. Med. Chem. , 2007 , 15 , 6450 .
6.
Fatemi
M.H.
, and
Gharaghani
S.
, Bioorg. Med. Chem. , 2007 , 15 , 7746 .
7.
Gao
M.
,
Wang
M.
,
Miller
K.D.
,
Hutchins
G.D.
, and
Zheng
Q-H.
, Appl. Radiat. Isotopes , 2010 , 68 , 110 .
8.
Kemnitzer
W.
,
Kasibhatla
Sh.
,
Jiang
S.
,
Zhang
H.
,
Zhao
J.
,
Jia
Sh.
, Bioorg. Med. Chem. Lett. , 2005 , 15 , 4745 .
9.
Kemnitzer
W.
,
Drewe
J.
,
Jiang
S.
,
Zhang
H.
,
Crogan-Grundy
C.
,
Labreque
D.
, J. Med. Chem. , 2008 , 51 , 417 .
10.
Kemnitzer
W.
,
Jiang
S.
,
Wang
Y.
,
Kasibhatla
Sh.
,
Crogan-Grundy
C.
,
Bubenik
M.
, Bioorg. Med. Chem. Lett. , 2008 , 18 , 603 .
11.
Kemnitzer
W.
,
Jiang
S.
,
Zhang
H.
,
Kasibhatla
Sh.
,
Crogan-Grundy
C.
,
Blais
Ch.
, Bioorg. Med. Chem. Lett. , 2008 , 18 , 5571 .
12.
liao
S.Y.
,
Qian
L.
,
Miao
T.F.
,
Shen
Y.
, and
Zheng
K.Ch.
, J. Theor. Comput. Chem. , 2009 , 8 , 143 .
13.
Elagamey
A.G.A.
, and
El-Taweel
F.M.
, Ind. J. Chem. 1990 , 29B , 885 .
14.
Kandeel
M.M.
,
Kamal
A.M.
,
Abdelall
E.K.A.
, and
Elshemy
Heba A.H.
, Org. Chem. Indian J. , 2012 , 8 , 342 .
15.
Skehan
P.
,
Scudiero
A.
,
Monks
A.
,
Mcmahan
J.
,
Vistica
D.
,
Warren
J.
,
Bokesch
S.
, and
Kenney
S.
, J. Nat. Cancer Inst. 1990 , 82 , 1107 .
