Abstract
Methylene homologues of chlorambucil were synthesised and conjugated to the labdane diterpene coronarin D. The products were evaluated for their in vitro cytotoxicity, and were found to exhibit selective activity against MOLT-3 cell line. Two homologues of chlorambucil showed a comparable cytotoxic effect to their parent. However, as compared with the non-derivatised chlorambucil and its homologues, their conjugation with coronarin D through ester linkage did not enhance in vitro cytotoxicity against the tested cancer cell lines.
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