Abstract
A mild and efficient method for the synthesis of thiopyrano[3,4-c]quinoline derivatives via an imino-Diels–Alder reaction of an aromatic aldehyde, 5-amino-1H-indazole or 2-aminoanthracene and tetrahydrothiopyran-4-one catalysed by iodine is described. This new procedure has the advantages of mild reaction conditions, high yields and metal-free catalysis. This is useful since quinoline and its derivatives have extensive biological activities.
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