Abstract
3-(3,4,5-Trimethoxyphenyl)propanoylpyrrole and 3-(3,5-dimethoxy-4-hydroxyphenyl)propanoylpyrrole, two new amide alkaloids, were prepared from 3,4,5-trimethoxybenzaldehyde via 3,4,5-trimethoxycinnamic acid and the corresponding dihydroacid. This route is simple and the reaction conditions are mild.
Keywords
References
1.
Rho M.C.
,
Lee S.W.
,
Park H.R.
,
Choi J.H.
,
Kang J.Y.
,
Kim K.
,
Lee H.S.
, and
Kim Y.K.
, Phytochemistry , 2007 , 68 , 899 .
2.
Duh C.Y.
,
Wu Y.C.
, and
Wang S.K.
, J. Nat. Prod. , 1990 , 53 , 1575 .
3.
Tsai I.L.
,
Lee F.P.
,
Wu C.C.
,
Duh C.Y.
,
Ishikawa T.
,
Chen J.J.
,
Chen Y.C.
,
Seki H.
, and
Chen I.S.
, Planta Med. , 2005 , 71 , 535 .
4.
Alécio A.C.
,
Bolzani V. da S.
,
Young M.C.M.
,
Kato M.J.
, and
Furlan M.
, J. Nat. Prod. , 1998 , 61 , 637 .
5.
Reddy S.V.
,
Srinivas P.V.
,
Praveen B.
,
Kishore K.H.
,
Raju B.C.
,
Murthy U.S.
, and
Rao J.M.
, Phytomedicine , 2004 , 11 , 697 .
6.
Park I.K.
,
Lee S.G.
,
Shin S.C.
,
Park J.D.
, and
Ahn Y.J.
, J. Agric. Food Chem. , 2002 , 50 , 1866 .
7.
Yang Y.C.
,
Lee S.G.
,
Lee H.K.
,
Kim M.K.
,
Lee S.H.
, and
Lee H.S.
, J. Agric. Food Chem. , 2002 , 50 , 3765 .
8.
Bodiwala H.S.
,
Singh G.
,
Singh R.
,
Dey C.S.
,
Sharma S.S.
,
Bhutani K.K.
, and
Singh I.P.
, J. Nat. Med. , 2007 , 61 , 418 .
9.
Lee E.B.
,
Shin K.H.
, and
Woo W.S.
, Arch. Pharm. Res. , 1984 , 7 , 127 .
10.
Yao C.Y.
,
Wang J.
,
Dong D.
,
Qian F.G.
,
Xie J.
, and
Pan S.L.
, Phytomedicine , 2009 , 16 , 823 .
11.
Tang G.H.
,
Chen D.M.
,
Qiu B.Y.
,
Sheng L.
,
Wang Y.H.
,
Hu G.W.
,
Zhao F.W.
,
Ma L.J.
,
Wang H.
,
Huang Q.Q
,
Xu J.J.
,
Long C.L.
, and
Li J.
, J. Nat. Prod. , 2011 , 74 , 45 .
12.
Pla D.
,
Marchal A.
,
Olsen C.A.
,
Francesch A.
,
Cuevas C.
,
Albericio F.
, and
Lvarez M.A.
, J. Med. Chem. , 2006 , 49 , 3257 .
13.
Rapoport H.
, and
Campion J.
, J. Am. Chem. Soc. , 1951 , 73 , 2239 .
14.
Frank H.R.
,
Fanta P.E.
, and
Tarbell D.S.
, J. Am. Chem. Soc. , 1948 , 70 , 2314 .