Abstract
A new series of 1,4-diaryl-1,4-dihydrochromeno[4,3-c]pyrazoles have been synthesised. The target compounds and their analogues (2,4-diaryl-2,4-dihydrochromeno[4,3-c]pyrazoles) were tested for their antitumour activities in vitro against MCF-7 and HL-60 cells using the MTT method. Among these compounds, 1,4-bis(4-chlorophenyl)-1,4-dihydrochromeno[4,3-c]pyrazole was found to have potent antitumour activity in vitro with minimum IC50 of 25.31 μg mL−1 and 13.86 μg mL−1 against MCF-7 and HL-60 cells respectively.
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