Abstract
A mild, efficient, and eco-friendly method for the Ugi reaction between a carboxylic acid, an amine, a carbonyl compound and an isocyanide to give a bisamide is described using PEG–H2O as a solvent. Reactants of poor water-solubility could be used in an aqueous medium without significant decrease in the yield. No side products were observed. The advantages of this protocol are short reaction time and easy isolation of the precipitated product when compared to reactions carried out in methanol.
Keywords
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