Abstract
A new series of 2-N-(phthalyl- or tosylamino acid)pyrimidines have been synthesised from the coupling of pyrimidine derivatives with phthalyl- or tosylamino acids. Hydrazinolysis of 2-N-phthalyl derivatives afforded unprotected amino acid derivatives. New derivatives of peptidylpyrimidines have been synthesised from the reaction of pyrimidine derivatives with α-amino acids methyl ester hydrochloride viz different routes. Also, new glycosides have been prepared from the reaction of pyrimidine derivatives with α-D-glucopyranosyl bromide. Most of the synthesised compounds showed a significant antimicrobial activity.
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