6-Trichloromethyl-9-oxa-5-azatricyclo[6.2.1.01,5]undecan-10-one was prepared and its structure clearly established from spectroscopic data and X-ray crystallography. The crystal structure belongs to the orthorhombic system, space group P212121 with a = 8.4494(17), b = 9.3505(19), c = 15.315(3) Å, α = β γ = 90°, V = 01210.0(4) Å3, Z = 4, Flack = 0.00(10). The absolute configuration of the title compound was determined as (1R,6R).
GeraldD., ArtmanIII, AlanW.G., and RobertM.W., J. Am. Chem. Soc., 2007, 129, 6336.
4.
SunM.R., LuH.T., and YangH., J. Chem. Res., 2009, 255.
5.
MichaelJ.P., Nat. Prod. Rep., 2008, 25, 139.
6.
LiddellJ.R., Nat. Prod. Rep., 2002, 19, 773.
7.
GarraffoH.M., CaceresJ., DalyJ.W., SpandeT.F., AndriamaharavoN.R., and AndriantsiferanaM., J. Nat. Prod., 1993, 56, 1016.
8.
KishoreN., MishraB.B., TripathiV., and TiwariV.K., Fitoterapia, 2009, 80, 149.
9.
PearsonM.S. M., Mathe-AllainmatM., FargeasV., and LebretonJ., Eur. J. Org. Chem., 2005, 2159.
10.
VilsmaierE.J., Prakt. Chem., 2000, 342, 218.
11.
VaneckoJ.A., and WestF.G., Heterocycles, 2007, 74, 125.
12.
BuffatM.G.P., Tetrahedron, 2004, 60, 1701.
13.
YodaH., Curr. Org. Chem., 2002, 6, 223.
14.
OrsiniF., PelizzoniF., ForteM., SistiM., BombieriG., and BenetolloF., J. Heterocyclic Chem., 1989, 26, 837.
15.
AnjanaM., LalitN.G., and DineshK.D., Indian J. Chem., 2003, 42B, 154.
16.
DIRDIF92: BeurskensP. T., AdmiraalG., BeurskensG., BosmanW.P., Garcia-GrandaS., GouldR.O., SmitsJ.M.M., and SmykallaC., The DIRDIF92 program system, Technical Report of the Crystallography Laboratory, University of Nijmegen, The Netherlands, 1992.17.
