Abstract
Water was found to promote the ligand-free Pd(OAc)2-catalysed Heck cross-coupling reaction. In the presence of 3 mol% Pd(OAc)2, 2 equiv. of Cs2CO3 and 15 mg of water, the coupling of a wide variety of aryl halides with alkenes proceeded smoothly in TBAB (n-Bu4NBr) in moderate to excellent yield. The Pd(OAc)2/TBAB system could be recovered and reused at least three times without loss of catalytic activity.
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