Abstract
4,6-Diarylpyrimidin-2(1H)-ones were effectively synthesised by utilising chlorotrimethylsilane (TMSCI) as an efficient promoter in the cyclisation condensation of arylketones, substituted benzaldehydes and urea by a one-pot, three-component reaction under air in DMF/CH3CN. The clean, mild reaction conditions, operational simplicity and high yields were attractive features of the reaction which enables a facile preparative procedure for building the pyrimidine ring.
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