Abstract
A novel synthetic route to chiral β-amino acid derivative has been developed by a Grignard reaction of 2,4,5-trifluo-rophenyl magnesium bromide with the Weinreb amide derivative of L-aspartic acid. The aspartic equivalent was synthesised from L-aspartic acid in four steps, and the Grignard reagent was prepared by Br–Mg-exchange reaction. The target compound was achieved after the Grignard reaction and a subsequent reduction. Tthe stereo structure of the chiral amine was well preserved from the L-aspartic acid.
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