Abstract
A new friedelane type triterpene, 3-oxo-11β-hydroxyfriedelane, named as monospermol, was isolated from the roots of Celastrus monospermus Roxb.(Celastraceae) along with seven known compounds friedelin, 3,12-dioxofriedelane, 3-oxo-28-hydroxyfriedelane, 3-oxo-12α-hydroxyfriedelane, β-sitosterol, pristimerin and celastrol. Structural formula and the stereochemistry of the new friedelane type triterpene 1 were established through 1H NMR and 13C NMR spectral data including 2D experiments (HMBC, HSQC, 1H-1H COSY and NOESY) and high resolution mass spectrometry.
References
1.
Sun C.R.
,
Hu H. J.
,
Xu R. S.
,
Yang J. H.
, and
Wan H. T.
, Molecules , 2009 , 14 , 2650 .
2.
Nozaki H.
,
Suzuki H.
,
Lee K.
, and
Mephail A.
, J. Chem. Soc. , 1982 , 18 , 1048 .
3.
Zhang K.
,
Liu J. L.
,
Wang Y. H.
,
Huang H. M.
, and
Chen Y. Z.
, Acta Sci. Nat. Uni. SunYatSen , 1998 , 37 , 85 .
4.
Liu Y.K.
, and
Wu D. G.
, Chinese traditional and herbal drugs , 1993 , 24 , 395 .
5.
He L.
,
Yue X. J.
,
Chen Y. Z.
,
Pan X.
,
Wu Y. J.
, and
Tang F. T.
, Chinese J. Appl. Chem. 1996 , 13 , 67 .
6.
Wang D.Y.
,
Li G. C.
,
Feng Y. J.
, and
Xu S. Y.
, J. Chem. Res. , 2008 , 655 .
7.
Wang D.Y.
,
Liu E. G.
, and
Feng Y. J.
, Chin. Chem. Lett. , 2008 , 19 , 547 .
8.
Chen M.X.
,
Wang D. Y.
,
Feng Y. J.
, and
Yang W.
, China J. Chin. Mater. Med. , 2009 , 17 , 2194 .
9.
Wang D.Y.
, and
Liu E. G.
, Nat. Prod. Res. , 2008 , 22 , 292 .
10.
Wang D.Y.
,
Liao H. W.
, and
Li X. M.
, Indian J. Heterocy. Chem. , 2006 , 15 , 367 .
11.
Amarendra P.
, and
Swapan K. C.
, Magn. Reson. Chem. , 1987 , 25 , 95 .
12.
Erasmienne T.N.
,
Rene S. F.
,
Silvere N.
,
Fabrice F. B.
,
Michel R.
,
Etienne T.
,
Jiri G.
, and
Philip J. R.
, Chem. Pharm. Bull. , 2008 , 56 , 374 .
13.
Mauro L.G. O.
,
Lucienir P. D.
,
Gracia D. F. S.
,
Sidney A. V. F.
,
Vagner F. K.
, and
Fernando G. P. A.
, Magn. Reson. Chem. , 2007 , 45 , 895 .
14.
Zhang Z.F.
, and
Bian B. L.
, Nat. Prod. Res. Dev. , 2007 , 19 , 237 .
15.
Chen Y.W.
,
Ding L. P.
, and
Ouyang M. A.
, Sultrop. Plant Sci. , 2007 , 36 , 79 .
16.
Franco D.M.
,
Giovanna B. M. B.
, and
Massimo P.
, J. Chem. Soc., Perkin Trans.1 , 1979 , 2649 .