Abstract
The transformation of the commercially available 2,3.4-trimethoxybenzaldehyde to 2,3,4,5-tetramethoxytoluene using a Dakin reaction to insert the extra oxygen, formylation, reduction and methylation of the phenolic hydroxyl group is described.
References
1.
Lipshutz B.H.
,
Lower A.
,
Berl V.
,
Sehcin K.
, and
Wetterrich F.
, Org. Lett. , 2005 , 7 , 4095 .
2.
Ibrahim W.H.
,
Blagavan H. N.
,
Chopra R. K.
, and
Chow C. K.
, J. Nutr. , 2000 , 130 , 2343 .
3.
Ernster L.
, and
Dallner G.
, Biochem. Biophys. Acta , 1995 , 1271 , 195 .
4.
Ji Y.
,
Xu W.
,
Jin W.
, and
Weimin Y.
, Synth. Commun. , 2006 , 36 , 1961 .
5.
Halsall C.H.
, Org. React. , 1957 , 9 , 73 .
6.
Hansen T.
, and
Skattebol L.
, Tetrahedron Lett , 2005 , 46 , 3357 .
7.
Wynberg H.
, Chem. Rev. , 1960 , 60 , 169 .
8.
Jutz C.
, Adv. Org. Chem. , 1976 , 1 , 225 .
