Electrogenerated base promoted synthesis of N -substituted-4-hydroxy-4-methylthiazolidine-2-thione derivatives

Abstract

Electrochemically-generated basic species from the reduction of acetonitrile assisted the condensation of carbon disulfide, primary arylmethylamines and chloroacetone to yield the corresponding N-substituted-4-hydroxy-4-methylthiazolidine-2-thione derivatives. In some cases, dehydration reaction led to the N-substituted-4-methylthiazole-2(3H)-thione analogues. The effect of the electrogenerated base amount on the reaction yield was also studied.