Phytochemical investigation of the radix of Angelica sinensis has led to the isolation two new ceramides, angelicamide A (1) and B (2), along with one known ceramide, (2S, 3S, 4R, 8E)-2-[(2′R)-2′-hydroxytetracosanoyl]-8-octadecene-1,3,4-triol (3). Their structures were determined by spectroscopic methods including IR, NMR (1D and 2D NMR) and MS. This is the first report on the occurrence of ceramides in the Angelica genus.
The State Pharmacopoeia Commission of P.R. China, The pharmacopoeia of the People's Republic of China, Chemical Industry Publishing Press, Beijing, China, 2005, p. 89.
2.
Nanjing University of Chinese Medicine, Dictionary of Chinese herbal medicines, 2nd edn, Shanghai Science and Technology Press, Shanghai, China, 2006, pp. 1207–1213.
3.
WangY.L., LiangY.Z., and ChenB.M., Phytochem. Anal., 2007, 18, 265.
4.
ZhengZ.H., DongZ.H., and SheJ., Chinese herb medicine modern study and application, Xueyuan Press, Beijing, China, 1997, Vol. 1, p. 807.
5.
YangX.B., ZhaoY., and LvY., Carbohydr. Polym. Chem., 2007, 71, 372.
6.
ZhaoK.J., DongT.T.X., TuP.F., SongZ.H., LoC.K., and TsimK.W.K., J. Agric. Food Chem., 2003, 51, 2576.
7.
DengS.X., ChenS.N., YaoP., DejanN., RichardB.B., JudyL.B., HarryH.S.F., NormanR.F., and GuidoF.P., J. Nat. Prod., 2006, 69, 536.
8.
LinM., ZhuC.D., SunQ.M., and FangQ.C., Yaoxue Xuebao, 1979, 14, 529.
9.
ChenY.Z., and ZhangH.D., Chem. J. Chin. Univ., 1984, 5, 515.
10.
HuangW.H., and SongC.Q., Zhongguo Zhongguo Zazhi, 2001, 26, 147.
11.
LinL.Z., HeX.G., LianL.Z., KingW., and ElliottJ., J. Chromatogr. A, 1998, 810, 71.
