Abstract
The neurosteroid antagonist, 3α,5α-17-phenylandrost-16-en-3-ol, which selectively antagonises the GABA-modulatory and GABA-mimetic effects of 3α,5α-tetrahydroprogesterone and related 5α-pregnanes, was synthesised by a new route using palladium-catalysed coupling reaction as a key step. Commercially available 3α-hydroxy-5α-androstan-17-one gave the desired product in 4 steps with an overall yield of 79.5%.
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