Abstract
Two trans polyphenolic stilbenes, Resveratrol and 3,4,4′,5- trans-tetrahydroxystilbene, were prepared in three steps from 4-methoxy phenylacetic acid and methoxylated benzaldehydes via a Perkin reaction. An interesting cis to trans isomerisation occured in the demethylation process in the presence of AlI3 and acetonitrile to give resveratrol and 3,4,4′,5-trans-tetrahydroxystilbene with overall yields of 51% and 48% respectively.
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