Free accessResearch articleFirst published online 2007-10
A One-Pot Synthesis of Functionalised 3-pyrolin-2-ones by a four-component reaction between Triphenylphosphine,Primary Amines,Dimethyl Acetylenedicarboxylate and Ethyl Chlorooxoacetate
Reaction between triphenylphosphine, dimethy acetylenedicarboxylate and amines produces phosphorus ylids which undergo a smooth reaction with ethyl chlorooxoacetate and triethylamine to produce dimethyl N-aryl-(or alkyl)-4-ethoxy-5-oxo-2,5-dihydro-1H-pyrole-2,3-dicarboxylates in high yields.
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