Medium-size Cyclophanes,75 1 Synthesis of anti-[2.3]metacyclophan-1-ene and Conversion to syn-1,2-epoxy[2.3]metacyclophane

Abstract

McMurry cyclisation of 1,3-bis(5-formyl-2-methoxyphenyl)propane afforded anti-6,13-dimethoxy[2.3]metacyclophan-1-ene, which was converted to the corresponding syn-1,2-epoxyl[2.3]metacyclophane by treatment of m-chloroperbenzoic acid.

Keywords

cyclophanes [2.3]metacyclophan-1-ene McMurry reaction conformation strained molecules epoxidation

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