The structure of 19(αH), 20(αH)-epoxycytochalasin D from the fungus Xylaria hypoxylon reported by Espada et al.,1 has been revised to 19(βH), 20(αH)-epoxycytochalasin D (1) by spectroscopic methods (1H NMR, 13C NMR, HMQC, HMBC, and NOESY), and single-crystal X-ray diffraction analysis. Cytotoxic activity against tumor cell line was assessed for compounds 1, and found to show potent cytotoxic activity against tumor cell line P-388.
PedersenE.J., LarsenP., and BollP.M., Tetrahedron Lett., 1980, 21, 5079.
11.
Crystal data: C30H37NO7.H2O, M = 541.64, monoclinic system, space group P 1 21 1; (a) 10.5850 (3); (b) 12.1369 (4); (c) 10.9613 (4) Å, V) 1408.18 (8) Å3, Z) 2: (d) 1.277 g/cm3. A crystal of dimensions 0.45 × 0.30 × 0.30 mm was used for measurements on a Rigaku/MSC four circle diffractometer. Crystallagraphic data for the structure of 1 has been deposited in the Cambridge Crystallographic Data Centre (deposition number: CCDC 286810). Copies of these data can be obtained, free of charge, on application to the CCDC via www.ccdc.com.ac.uk/conts/retrieving.html (or 12 Union Road, Cambridge CB2 1EZ, UK; fax: + 44 1223 336033; e-mail: deposit@ccdc.cam.ac.uk).
12.
AbateD., AbrahamW.R., and MeyerH., Phytochemistry, 1997, 44, 1443.
13.
PauwelsB., KorstA.E.C., De PooterC.M.J., PattynG.G.O., LambrechtsH.A.J., BaayM.F.D., LardonF., and VermorkenJ.B., Cancer Chemother Pharmacol, 2003, 51, 221.
