A series of 5,7-diarylpyrido[2,3-d]pyrimidine derivatives were synthesised by the reaction of 1,3-diaryl-2-propen-1-ones with 6-aminouracil in ethanol at 80°C catalysed by KF-Al2O3. The structure of one of the products was confirmed by X-ray analysis.
MongeA., Martinez-MerinoV., SanmartinC., FernandezF.J., OchoaM.C., BerllverC., ArtigasP., and Fernandez-AlvarezE., Eur. J. Med. Chem., 1989, 24, 209.
11.
SaladowskaH., Bartoszko-MalikA., and ZawiszaT., Farmaco1990, 45, 101.
12.
ClarkJ.H., Chem. Rev., 1980, 80, 429; (b) J.W. ApSimon, J.W. Hooper and B.A. Laishes, Can. J. Chem., 1970, 48, 3064.
13.
AndoT., YamawakiJ., KawateT., SumiS., and HanafusaT., Bull. Chem. Soc. Japan1982, 55, 2504; (b) J. Yamawaki, T. Ando and T. Hanafusa, Chem. Lett., 1981, 1143.
14.
GaoY., ShiD.Q., ZhouL.H., and DaiG.Y., Chinese J. Org. Chem., 1996, 16, 548.
15.
MelotM., BoulletF.M., and FoucaudA., Tetrahedron Lett., 1986, 27, 493.
X-ray crystallography for 3a: Crystallographic data for the structure 3a reported in this paper has been deposited at the Cambridge Crystallographic Data Centre as supplementary publication with No. CCDC-291527. Copies of available material can be obtained, free of charge, on application to the Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK, (fax: + 44-(0) 1223-336033 or e-mail: deposit@ccdc.cam.ac.uk). Empirical formula C19H12ClN3O2·HCON(CH3)2, FW = 422.86, T = 193(2) K, triclinic, space group P-1, a = 7.6985(7) Å, b = 11.7486(10) Å, c = 12.0533(8) Å, α = 72.813(7), β = 72.868(7), γ = 80.952(8) °, V = 992.34(14) Å3, Z = 2, Dc = 1.415 Mg/m3, λ (MoKα) = 0.71070Å, μ = 0.225 mm−1, F(000) = 440, 3.03°<θ<25.35°, R = 0.0377, wR = 0.0904. S = 1.075, Largest diff. peak and hole: 0.234 and −0.252 e·Å−3
22.
SubbaR.A., and MitraR.B., Indian J. Chem.1981, 20B, 159; (b) S. Wawzonek, J. Org. Chem., 1976, 41, 3149.
23.
FanN.T., The Handbook of Organic Synthesis, Beijing Institute of Technology Press, Beijing: 1995, p. 758.
