α-Hydroxyketones were prepared in appreciable yields at a very high speed, (by the benzoin condensation) under microwave irradiation using a catalytic amount of thiamine hydrochloride, from various aromatic as well as heteroaromatic aldehydes. They can be used as intermediates in NCE synthesis.
LutzR.E., and MurphyR. S., J. Am. Chem. Soc., 1949, 71, 478.
3.
ProcopiouP.A., DraperC. D., HutsonJ. L., InglisG. G. A., RossB. C., and WatsonN. S., J. Med. Chem., 1993, 36, 3658.
4.
MeanwellN.A., RosenfeldM. J., TrehanA. K., RomineJ. L., WrightJ. J. K., BrassardC. L., BuchananJ. O., FedericiM. E., FlemingJ. S., GamberdellaM., ZavoicoG. B., and SeilerS. M., J. Med. Chem., 1992, 35, 3498.
5.
Van EsT., and BackebergO. G., J. Chem. Soc., 1963, 1371.
6.
(a) DeschampsI., KingW. J., and NordF. F., J. Org. Chem., 1949, 14, 184.
StetterH., RamschR. Y., and KuhlmannH., Synthesis, 1976, 733.
22.
(a) FurnissB.S., HannafordA. J., SmithP. W. G., and TatchellA. R., Vogel's Text book of Practical Organic Chemistry, 5th edn.; ELBS and Longman, 1994, pp. 1044.
23.
IdleW.S., and BuckJ. S., Org. React., 1948, 4, 269.
24.
MndzhoyanO.L., GamburyanA. A., PapoyanL. S., GerasimyanJ. A., SrapionyanR. M., GrigoryanL. A., BagdasaryanA. A., MelkonyanD. A., DurgaryanL. K., and AkopyanA. V., Khim. Farmats. Zh., Chem Abstr., 115: 49002, 1991, 25, 28.
