A facile regioselective synthetic approach towards 1,3,4,8,10,11-hexaaryl-13-methyl-1,2,8,9,13-pentaazadispiro [4.1.4.3]tetradeca-2,9-dien-6-ones 3a–g was achieved through the reaction of 3,5-bis(arylmethylene)-1-methyl-4-piperidinones 1a–f with nitrilimines (generated in situ by triethylamine dehydrohalogenation of the corresponding hydrazonoyl chlorides 2a,b). The stereochemical configuration of the isolated products was established to be 4S, 5R, 7R, 11S based on a single crystal X-ray diffraction study of 3b.
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