Abstract
The reactive intermediate generated by the reaction of alkyl isocyanides and dialkyl acetylenedicarboxylates was trapped by aromatic amides to produce unsaturated amidine derivatives in good yield.
References
1.
Ugi I.
, In Isonitrile Chemistry , Academic Press , London , 1971 .
2.
Ugi I.
, Angew. Chem. Int. Ed. , 1982 , 21 , 810 .
3.
Domling A.
, and
Ugi I.
, Angew. Chem. Int. Ed. , 2000 , 39 , 3168 .
4.
Walborsky H.M.
,
Periasamy M. P.
,
Patai S.
, and
Rappoport Z.
, (eds) In The Chemistry of Functional Groups , Supplement, C. Wiley , New York , chap. 20, p 835 .
5.
Marcaccini S.
, and
Torroba T.
, Org. Prep. Proc. Int. , 1993 , 25 , 141 .
6.
Nair V.
,
Vinod A. U.
,
Menon N. R. S.
,
Santhi V.
,
Varma R. L.
,
Viji S.
,
Mathew S.
, and
Srinivas R.
, Tetrahedron , 2003 , 59 , 10279 .
7.
Oakes T.R.
, and
Donovan D. J.
, J. Org. Chem. , 1973 , 38 , 7 .
8.
Yavari I.
,
Anary-Abbasinejad M.
,
Alizadeh A.
, and
Hossaini Z.
, Tetrahedron , 2003 , 59 , 1289 .
9.
Yavari I.
,
Djahaniani H.
, and
Nasiri F.
, Tetrahedron , 2003 , 59 , 9409 .
