Abstract
A new class of phosphorus macroheterocycles (4a–j) has been synthesised in two steps. The reaction of 1 mole of 3,4-diamino-1,2,5-oxadiazole (1) with 2 moles of aqueous formaldehyde gave a Schiff's base which subsequently underwent addition with 2 moles of 4-t-butylphenol in 1,4-dioxane, afforded N,N-bis-(5-t-butyl-2-hydroxybenzyl)furazan-3,4-diamine (2). Cyclisation of 2 in situ with various substituted aryl phosphorodichloridates (3a–j) in the presence of Et3N in THF afforded 13-membered macroheterocycles (4a–j) containing P, N, O and C in good yields.
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