Reaction between Alkyl or Aryl Isocyanides and Dialkyl Acetylenedicarboxylates in the Presence of N,N′-dimethylbarbituric Acid: Synthesis of 4H-pyrano[2,3-d]pyrimidines
Free accessResearch articleFirst published online June, 2005
Reaction between Alkyl or Aryl Isocyanides and Dialkyl Acetylenedicarboxylates in the Presence of N,N′-dimethylbarbituric Acid: Synthesis of 4H-pyrano[2,3-d]pyrimidines
The highly reactive 1:1 adduct produced in the reaction between alkyl or aryl isocyanides and dialkyl acetylenedicarboxylates is trapped by N,N′-dimethylbarbituric acid to yield 4H-pyrano[2,3-d]pyrimidine derivatives.
