Abstract
7α-[(S)-2-Hydroxy-2-(2-thienyl)ethyl]-6,14-endoethanotetrahydrothebaine was synthesised and studied by 1H NMR and MS spectroscopy, its crystal structure was determined by X-ray diffraction.
References
1.
(a)
Lewis J.W.
,
Readhead M. J.
,
Smith A. C. B.
J. Med. Chem. , 1973 , 16 , 9 .
2.
Zimmerman D.M.
,
Leander J. D.
J. Med. Chem. , 1999 , 33 , 895 .
3.
Portnoy R.K.
, In Proceedings of the 7th World Congress on Pain , Progress in Pain Research and Management.
Crebhart G.F.
,
Hammond D. L.
,
Jensen T. S.
, Eds. IASP , Seattle, WA , 1994 , 29 , 595 .
4.
Crome H.B.
, Drug Alcohol Depend. , 1999 , 55 , 247
5.
(a)
Bentley K. W.
, In Central Analgetics ,
Lednicer D.
, Ed. John Wiley & Sons : New York , 1982 ; 152 .
6.
Marton J.
,
Simon Cs.
,
Hosztafi S.
,
Szabo Z.
,
Marki A.
,
Borsodi A.
,
Makleit S.
Bioorg. Med. Chem. , 1997 , 5 , 369 .
7.
Husbands S.M.
,
Lewis J. W.
J. Med. Chem. , 2000 , 43 , 139 .
8.
(a)
Heel R.C.
,
Brogden R. N.
,
Speight T. M.
,
Avery G. S.
, Drugs , 1979 , 17 , 81 . (b) P.J. Hoskin, G.W. Hanks, Drugs 1991, 41 , 326
9.
Takemori A.E.
,
Hayashi G.
,
Smits S. E.
, Eur. J. Pharmacol. , 1972 , 20 , 85 .
10.
Wang D.X.
,
Lu X. Q.
,
Qin B. Y.
, J. Pharm. Pharmacol. , 1995 , 47 , 669 .
11.
Gylbert L.
, Acta Crystallogr., B , 1973 , 29 , 1630 .
12.
Van den Hende K.W.
,
Nelson N. R.
, J. Am. Chem. Soc. , 1967 , 89 , 2901 .
13.
Kratochvil B.
,
Husak M.
,
Bulej P.
,
Jegorov A.
, Collect. Czech. Chem. Comm. , 1994 , 59 , 2472 .
14.
Cram D.J.
,
Elhafez F. A. A.
, J. Am. Chem. Soc. , 1952 , 74 , 5828 .
15.
Bentley K.W.
,
Hardy D. G.
,
Meek B.
J. Am. Chem. Soc. , 1967 , 89 , 3273 .
16.
Sheldrick G.M.
, SHELXS-97, Program for X-ray Crystal Structure Solution , Göttingen University , Germany 1997 . G.M. Sheldrick, SHELXL-97, Program for X-ray Crystal Structure Refinement , Göttingen University, Germany 1997.
17.
Blessing R.H.
, Acta Crystallogr. , 1995 , A51 , 33 .