Abstract
A N-methylpyrrole containing polyamide/peptide conjugates which are synthetic analogues of natural products with DNA affinity was synthesised. It can efficiently hydrolyse PUC19 plasmid DNA. The structure of these compound was confirmed by 1H NMR, MS and IR.
References
1.
Wade W.S.
,
Mrksich M. M.
, and
Dervan P. B.
, J. Am. Chem. Soc. , 1992 , 114 , 8783 .
2.
Trauger J.W.
,
Baird E. E.
, and
Dervan P. B.
, Nature , 1996 , 382 , 559 .
3.
White S.
,
Baird E. E.
, and
Dervan P. B.
, Chem. Biol. , 1997 , 4 , 569 .
4.
Gottesfeld J.M.
,
Neely L.
,
Trauger J. W.
,
Baird E. E.
, and
Dervan P. B.
, Nature , 1997 , 387 , 202 .
5.
Dickinson L.A.
,
Gulizia R. J
,
Trauger J. W.
,
Baird E. E.
,
Mosier D. E.
,
Gottesfeld J. M.
, and
Dervan P. B.
Proc. Natl. Acad. Sci. U.S.A. , 1998 , 95 , 12890 .
6.
Dickinson L.A.
,
Trauger J. W.
,
Baird E. E.
, Biochemistry , 1999 , 38 , 10801 .
7.
Dickinson L.A.
,
Trauger J. W.
,
Baird E. E.
,
Ghazal P.
,
Dervan P. B.
, and
Gottesfeld J. M.
, Biochemistry , 1999 , 38 , 10801 .
8.
Geierstanger B.H.
,
Mrksich M.
,
Dervan P. B.
, and
Wemmer D. E.
, Science , 1994 , 266 , 646 .
9.
Kielkopf C.L.
,
Baird E. E.
,
Dervan P. B.
, and
Rees D. C.
, Nat. Struct. Biol. , 1998 , 5 , 104 .
10.
White S.
,
Szewcayk J. W.
,
Turner J. M.
,
Baird E. E.
, and
Dervan P. B
, Nature , 1998 , 391 , 468 .
11.
Kielkopf C.L.
,
White S. E.
,
Szewczyk J. W.
,
Turner J. M.
,
Baird E. E.
,
Dervan P. D.
, and
Rees D. C.
, Science , 1998 , 282 , 111
12.
Li Y.S.
,
Zhao Y. F.
,
Hatfield S.
,
Wan R.
,
Zhu Q.
,
Li X. H.
,
McMills M
,
Ma Y
,
Li J
,
Brown K. L.
,
He C.
,
Liu F.
, and
Chen X. Z.
, Bioorg. Med. Chem. , 2000 , 8 , 2675 .
13.
Chen J.
,
Wan R.
,
Liu H.
,
Cheng C. M.
, and
Zhao Y. F.
, Lett. Peptide Sci. , 2001 , 7 , 325 .
14.
Nishiwaki E.
,
Tanaka S.
,
Lee H.
, and
Shibuya M.
, Heterocycles , 1988 , 27 , 1945K . Weisz, Angew. Chem., Int. Ed. Engl. , 1997, 36 , 2592.
15.
Baird E.E.
, and
Dervan P. B.
, J. Am. Chem. Soc. , 1996 , 118 , 6141 .
